A new hope for diabetics .. "smart insulin" work if necessary

Researchers have developed a new composition of insulin that has an incredible ability to respond to the levels of blood sugar in real time, and the new composition can revolve millions of people with type 1 diabetes around the world. Researchers from the United States, Australia and China have managed to develop a new form of insulin that mimics the body’s natural response to fluctuations in blood sugar levels as it responds immediately, such as a healthy pancreas. This new treatment, called ‘smart insulin’, remains in the body until needed, and responds immediately to high blood sugar levels, and helps maintain balance without regular injections. “Smart Insulin” is still at the stages of development and testing, but the potential of transforming the lives of people with type 1 diabetes is indescribable. For Type 1 diabetics, blood sugar levels manage a daily challenge that is inevitable, as patients currently have an artificial insulin up to ten times a day to survive. Continuous fluctuations between high and low blood sugar levels in the blood can lead to physical health problems in the short and long term, and efforts to maintain stability levels also affect the mental health of patients. Diabetes management is a global health problem that causes high blood glucose levels during fasting or high blood sugar, while insulin is used to manage diabetes, it is a hormone produced by the pancreas, and the blood sugar levels regulate by sending and storing glycogen and muscle. Type 1 diabetes is caused by the self -destruction of insulin -producing cells, leading to insulin deficiency, while type 2 diabetes is characterized by insulin resistance, despite normal or high insulin levels. Other forms, such as diabetes during pregnancy, lead to similar problems in the blood glucose level, which often require accurate handling with the help of insulin. The management of diabetes involves self -management of external insulin, especially for those with type 1 diabetes, and advanced type 2 diabetes. However, strict control over blood sugar levels is difficult, and poor compliance with insulin treatment can lead to serious complications. For example, low blood sugar can cause coma or even death, while the instability of glucose in chronic blood levels can contribute to cardiovascular disease and other serious health problems. Although insulin formulas that provide more predictive pharmaceutical movement have been made, there is still a great need for better tools to achieve accurate control of blood sugar and to avoid immediate and long -term complications. Traditional insulin treatments stabilize blood sugar levels after a short time of injection, but its effects are temporary, and with blood sugar levels in volatility throughout the day, patients often find themselves extra injection after a few hours. This course of repeated doses causes physical and mental fatigue, and does not provide a stable type of long -term control that is very important for optimal health. How to make smart insulin. The new treatment belongs to a category of medicine known as ‘smart medication’, which is medicine designed to provide treatment in a more accurate and controlled treatment compared to traditional medicine. Smart medicine is characterized by their ability to respond to certain stimuli or conditions in the body, such as changes in pH or temperature or the presence of certain molecules such as glucose, and this allows the release of the drug or activation thereof, if necessary, which reduces the side effects, and improves the effectiveness of treatment. Smart medicine is part of the broader field of smart medicine delivery systems, which aim to improve the results of treatment by targeting specific sites or cases within the body, thereby increasing the effectiveness of treatment, while minimizing the risks. The biggest challenge in developing smart medicine delivery systems was to create installations that can automatically experience glucose levels and connect the appropriate dose of insulin. The new smart medicine aims to achieve insulin treatment with a closed loop, as insulin compound is fully regulated based on the actual time monitoring. Dr Tim Hayes, vice chairman of the new Insulin Scientific Consulting Committee, said that smart insulin could enter a new era in the war against diabetes, according to the British newspaper “The Guardian”. He added: “Even with the insulin currently available, people living with type 1 diabetes should put a lot of effort into finding diabetes they have every day, a good balance between acceptable control of blood sugar on the one hand and to avoid blood sugar on the other.” He continued: “The new insulin is seen as glucose as closest to the treatment of type 1 diabetes.” Nearly 3 million pounds were granted for six research projects that developed different types of smart insulin. These projects include teams from Stanford University in the United States, Monash University in Australia and the University of Zhejiang in China. The goal is to accelerate development and launch experiments as soon as possible. Each project aims to control smart insulin to work faster and more accurately, and to reduce some or all the major burden of managing type 1 diabetes and reduce the risk of long -term complications. “While Insulin has been saving for more than 100 years of lives, previous research has caused important changes to people with the first type, but it is still not good enough,” says Rachel Connor, director of research partnerships at JDRF UK. There are three main strategies to integrate glucose observation into these formulas: “Enzymatic observation, glucose -related protein and artificial molecular recognition.” Each approach showed promising results, but there were major obstacles to improve the response time, ensuring the exact control of blood sugar, increasing the biological compatibility and the safety of used substances. The new smart insulin does not become an active glucose, except when there is a certain amount of blood sugar to prevent high blood sugar, while again it becomes incomplete if the levels fall below a certain point, which occurs hypoglycaemia. Experts believe that patients need insulin only once a week. The researchers said that smart insulin proclaims a new era in the war against diabetes. A date behind innovation decades ago has developed scientists substances that respond to glucose, insulin that secretes the blood from the high sugar levels, using lactines, a group of proteins associated with carbohydrates. One of the most studied lactins is the ‘Concanavaline’, which was used in different ways to sensitize glucose levels. This concept was first investigated in 1979, when the researchers showed that insulin could be launched in response to glucose by integrating it with Congle. Over time, this idea was expanded by integrating conglene into polymers or microscopic capsules, enabling the insulin -controlled release. And when glucose levels rise, glucose molecules compete with insulin to link to the cornavaline, leading to the release of insulin as needed. Another innovative approach includes the use of Congle as a band to create aqueous gels of polymer. These water -made gels, made from synthetic polymers, respond to glucose by swelling, as glucose disrupts the crossbonds of the Congonavaline, and this process can be used to create hydrogen equipment that launch insulin when glucose levels rise. By controlling the balance in hydrogel, scientists can accurately control the insulin introduction. Another way can be used to make smart insulin, instead of relying on s -elements natural glucose notification, such as lactins or enzymes, researchers can use artificial molecules, such as vinyl bureaucic acids to connect glucose. It is known that the vinyl bids are inversely linked to glucose and other similar molecules, making it effective in the violent glucose systems. The development of glucose -response substances for medication is a great progress in dealing with diabetes, as it can provide a more dynamic and safe way to give insulin. According to the researchers, the development of smart insulin, which responds to the levels of sugar that turns into the blood in real time, is a leading progress in the care of diabetics who have the ability to dramatically reduce the daily burden on millions of people living with type 1 diabetes. New research can cause a revolution in the treatment of diabetes by giving a better control of blood sugar, reducing the risk of complications, and alleviating mental and physical challenges associated with this condition. And he proclaims ‘smart insulin’ with a new era in the management of diabetes, which gives hope in a future in which diabetes management is less challenging and smoother.