Intestinal immune cell interactions | VUMC Reporter

by Leigh MacMillan

A number of forms of immune cells are interspersed among the many epithelial cells lining the intestines and are thought of to be a primary line of protection towards pathogens. The survival and interplay of those intraepithelial lymphocytes and their roles in intestinal irritation should not effectively understood.

Ali Nazmi, PhD, Danyvid Olivares-Villagómez, PhD, and colleagues have examined the impact of 1 sort of intraepithelial lymphocyte (iCD8alpha) on one other (ILC1-like). Utilizing mice with diminished numbers of iCD8alpha cells, they discovered that these cells play a important position within the survival of ILC1-like cells, and that this impact is partly mediated by the issue osteopontin.

In a mouse mannequin of intestinal irritation that entails ILC1-like cells, diminished iCD8alpha cell numbers resulted in milder irritation and remedy with osteopontin elevated illness severity.

The findings, reported in PLOS ONE, implicate iCD8alpha cells in ILC1-like cell survival and intestinal irritation and add to the rising roles of osteopontin in numerous organic processes.

This analysis was supported by the Nationwide Institutes of Well being (grants DK111671, LM000745) and by the American Affiliation of Immunologists.