Tag Archives: Chemistry

NIH grant helps Vanderbilt effort to extend variety

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A brand new $2.5 million grant from the Nationwide Institutes of Well being is enabling Vanderbilt College chemist Renã A.S. Robinson to develop her analysis on racial disparities in Alzheimer’s and different illnesses. Robinson, an affiliate professor of chemistry and Dorothy J. Wingfield Phillips Chancellor School Fellow, is the co-principal investigator on the R01 grant, which is designed to develop and check recruiting supplies geared toward encouraging older African Individuals to take part in Alzheimer’s analysis.

Rena Robinson (Vanderbilt College/Joe Howell)

An article concerning the analysis, “Framework for Creating Storytelling Supplies to Promote African American/Black Grownup Enrollment in Analysis on Alzheimer’s Illness and Associated Issues” was printed within the journal Alzheimer’s & Dementia: Translational Analysis & Medical Interventions on Sept. 11.

Alzheimer’s illness impacts African Individuals at twice the speed it does whites, and preliminary analysis by Robinson exhibits that extra could be realized about Alzheimer’s illness by finding out biospecimens from African Individuals. Nonetheless, African Individuals are profoundly underrepresented in Alzheimer’s analysis, making it tough for researchers, together with Robinson, to completely perceive why these variations happen and the right way to deal with them successfully.

“As a way to undertake really inclusive research, the analysis group wants a greater technique to join with African Individuals who might have considerations about volunteering,” mentioned Robinson. “Our hope is to develop supplies that talk to the distinctive questions and significant considerations African Individuals might have about collaborating in analysis.”

African Individuals face quite a few limitations to collaborating in Alzheimer’s analysis. They are typically recognized later than whites, have much less details about the illness, really feel larger stigma across the illness, and have excessive ranges of medical distrust on account of this nation’s lengthy historical past of racism, the latter being some of the important limitations. Researchers have sought to handle these limitations lately by means of numerous different kinds of outreach and schooling methods, however gaps stay.

Within the first section of their analysis, Robinson and co-principal investigator Jennifer Lingler, with co-investigators Judy Cameron, Ishan Williams and Keisha Ward, designed and examined the enchantment of a novel storytelling strategy to make use of in printed and video recruitment supplies. Utilizing ethnographic interviews with African American analysis members and examine companions on the College of Pittsburgh Alzheimer’s Illness Analysis Middle, the group developed six distinct characters, or personas, to inform their tales about why they determined to take part and what the method was like for them.

Lingler, a professor on the College of Pittsburgh College of Nursing, has led the Outreach, Recruitment and Engagement Core of the ADRC for greater than 10 years. “What’s particularly difficult about recruiting members for Alzheimer’s analysis is that research are sometimes looking for people who aren’t experiencing any signs of the illness,” Lingler mentioned. “Storytelling holds actual potential to interrupt by means of these challenges.”

The tales centered on themes of group, inclusion and social change, emphasizing the ways in which analysis members give again to the group, and to assist in giving peace of thoughts to their households. As a substitute of portraying sufferers as victims, the supplies highlighted their position as very important companions within the Alzheimer’s battle. Focus group suggestions was encouraging sufficient to help additional growth.

With help from the NIH, the group has been refining and testing the messaging and supplies developed within the Pittsburgh space, and is now increasing to adapt this strategy for Nashville. “Geography issues,” mentioned Robinson. “Older African Individuals within the South have completely different life experiences than these within the Northeast, regardless of many having migrated to the North in early- to mid-adult life. These experiences strongly affect their beliefs about collaborating in medical analysis. The variety of those tales throughout the U.S. is necessary to partaking African Individuals in Alzheimer’s illness analysis.”

Robinson mentioned these findings will inform greatest practices for outreach to African Individuals throughout the nation—and, in the end, assist make Alzheimer’s analysis extra inclusive. “We are able to’t really perceive how Alzheimer’s works till we all know the way it works in everybody,” she mentioned.

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103-year-old ex-chemist to be honored for work on penicillin

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The story is household lore. In 1942, chemist Robert Walton, then in his late 20s, was drafted following the assaults on Pearl Harbor and boarded a bus in Rahway, New Jersey, for primary coaching at Fort Dix.

His journey lasted just a few miles (kilometers) when FBI brokers boarded the bus and defined that Walton needed to return to work at his laboratory at close by Merck & Co. His mission: to increase provides of penicillin.

“Audrey wasn’t even shocked once I went again for supper,” Walton, now 103, recalled of his younger spouse’s nonchalant response when he walked by means of the door that night time.

Walton and his legacy lately caught the attention of the Columbus chapter of the Navy Order of The Purple Coronary heart, which requested him to put a wreath on the group’s monument on the Nationwide Veterans Memorial and Museum in Columbus on Aug. 7, which is nationwide Purple Coronary heart Day.

The work Walton and others did saved tens of millions of lives, mentioned chapter head Tom Beck, a Korean Struggle veteran wounded throughout a mine-clearing operation in January 1953.

“All we need to do is make sure that he is aware of that there are individuals who respect his work,” mentioned Beck, 86, a retired trainer in suburban Columbus.

The antibacterial properties of penicillin had been first recognized in a British laboratory in 1928, however it wasn’t till 1941 that it was examined on people with promising outcomes. Unable to mass-produce penicillin due to the conflict, Britain turned to the U.S. authorities and U.S. manufacturing corporations, together with Merck, Pfizer, Squib and others.

The federal government took over all manufacturing of penicillin when conflict broke out. Utilizing corn steep liquor, a waste product from producing corn starch, researchers at a U.S. Division of Agriculture lab in Peoria, Illinois, helped enhance provides.

The following outcomes confirmed the facility of conflict time equipment, mentioned Robert Gaynes, an Emory College professor and doctor and an knowledgeable on the historical past of penicillin’s growth and manufacturing.

In 1941, the USA didn’t have sufficient penicillin to deal with a single affected person, Gaynes wrote within the journal Rising Infectious Illnesses in 2017. “By September 1943, nevertheless, the inventory was ample to fulfill the calls for of the Allied Armed Forces,” he wrote.

“To have produced that a lot that quick is a tribute to everybody concerned,” Gaynes mentioned in an interview final week.

Walton, who later earned his PhD from Rutgers College, spent a 40-year profession with Merck in New Jersey, retiring “a while in the past” he mentioned with a smile, sitting in his daughter’s dwelling. (In 1981, to be exact.)

His many accomplishments embrace a patent for Pneumovax, a pneumonia vaccine. He moved to Columbus a number of years again following the dying of his spouse after 73 years of marriage.

His daughter, Wendy Walton Reichenbach, 67 and likewise a retired chemist, wrote a first-person account of her father for The Columbus Dispatch final month, explaining the household’s pleasure in his work.

“On a latest patriotic vacation, I thanked my dad ‘for his service to our nation,’ as I do virtually yearly,” she wrote. “His response — ‘When you say so’ — has been the identical yearly for many years. He has by no means felt that he ‘served.'”

Walton was laborious pressed to explain his war-time service in something past scientific phrases, recounting the meticulous work to develop mediums for the submerged progress of penicillium — the mildew — which was essential for large-scale penicillin manufacturing.

He expressed shock on the Purple Coronary heart group’s admiration of his work and want to honor him.

“Effectively, it was simply my job,” he mentioned.

———

Related Press researcher Jennifer Farrar in New York Metropolis contributed to this report.

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[Biology] #everydayscience_biology 今日等我黎講下滲透(osmosis)啦 喺日常生活入面我地未必會成日都聽到滲透呢一樣野,但…

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#🤓everydayscience_biology
今日等我黎講下滲透(osmosis)啦😆
喺日常生活入面我地未必會成日都聽到滲透呢一樣野,但係其實佢喺好多地方都進行緊。滲透係水分子經過半透膜擴散嘅一個現象。水分子會由高水勢嘅區域滲入去低水勢嘅區域,直至細胞入面同細胞外面嘅濃度達到平衡為止。
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細胞會藉住滲透作用黎吸到水分又或者係喪失水分。但係有可能會因為咁而得到過多嘅水分又或者係失去太多嘅水。
或者用個例子黎講會比較易明。當我地將細胞放入濃嘅鹽水入面,由於濃嘅鹽水入面水的含量比例比細胞質低,細胞入面嘅水會不斷咁向細胞外面滲透,導致細胞脫水同萎縮。相反,將細胞放入蒸餾水入面嘅話呢,由於細胞入面嘅水含量比例比蒸餾水低,外面嘅水分子會不斷咁向細胞入面滲透,導致細胞膨脹,甚至破裂。
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而對於植物細胞呢,因為佢地嘅細胞壁同細胞膜嘅滲透性唔一樣,當細胞外嘅濃度高過入面嘅時候,細胞會出現質壁分離嘅現象,即係細胞壁同細胞膜分離。但係當佢地吸返水之後就會出現質壁分離嘅復原現象。
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#everydayscience #science #physics #chemistry #biology #plants #animals #organisms #livingthings #earth #mothernature #chloroplasts #ATP #mitochondria #foodproducer #energy #foodchain #originoflife #question #nevergiveup #AlbertEinstein #nature #world #cells #cellmembrane #osmosis

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[Biology] #everydayscience_biology 其實part 2只係part 1嘅Eng version聽日會再有多啲補充 Osmosis…

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#🤓everydayscience_biology
其實part 2只係part 1嘅Eng version🙈聽日會再有多啲補充😆
Osmosis refers to the net movement of water molecules from a region of higher water potential to a region of lower water potential through a differentially permeable membrane. Water potential refers to the tendency of a water molecule to move from one place to another.
Cells would gain or lose water by osmosis. However, osmosis may cause excessive water gain or water loss, which may affect the normal functioning of cells. When the cells gain too much water, the cell content is diluted. On the contrary, when the cells lose too much water, the cell content will be concentrated, and the viscosity increases.
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Take red blood cell as an example. When we put some red blood cells into concentrated saline solution, as the conc saline solution has a lower water potential, water in the cell leaves by osmosis, causing the cell to lose water and shrink. In contrast, when we put the red blood cells into distilled water, the cells will gain water by osmosis as the water potential of distilled water is higher than that of the cytoplasm. Water enters the cells by osmosis, causing them to swell, and even burst.
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For plant cells, as they have rigid cell walls, so they won’t burst. But plasmolysis occurs when they lose too much water, this causes the plant to lose turgidity. When they gain water again, they become turgid.
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#everydayscience #science #physics #chemistry #biology #plants #animals #organisms #livingthings #earth #mothernature #chloroplasts #ATP #mitochondria #foodproducer #energy #foodchain #originoflife #question #nevergiveup #AlbertEinstein #nature #world #cells #cellmembrane #osmosis

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The Periodic Table Song



Check out our UPDATED version which has all the NEW ELEMENTS here: https://youtu.be/rz4Dd1I_fX0 Download on ITUNES: http://bit.ly/12AeW99 DOWNLOAD ON BANDCAMP: http://bit.ly/111Kssd (instrument…

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The Periodic Table Song (2018 UPDATE!)



The COMPLETE Periodic Table! Check out http://asapscience.com for more iTunes http://bit.ly/asaptable Bandcamp: https://asapscience.bandcamp.com/track/the-updated-periodic-table-song-2018 …

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THE SAGAN SERIES – The Frontier Is Everywhere

[youtube https://www.youtube.com/watch?v=oY59wZdCDo0&w=580&h=385]

For more Facebook – http://www.facebook.com/thesaganseries Twitter – http://twitter.com/reidgower G+ – http://bit.ly/VpHzQh The Sagan Series is an educational project working in the hopes…

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