Study: Long -term obesity accelerates biological aging among young people

A recent and detailed study revealed that long -term obesity was linked to the rise of signs of molecular aging of youth. The study published in the Journal of the American Medical Association said that obesity leads to a very early physiological decline; And at a time earlier than he believed many. The study, conducted on a group of young people in Chile, between the ages of 28 and 31, provides conclusive evidence that obesity is not just a risk factor for chronic diseases, but rather is a catalyst for the accelerated biological aging itself. Obesity is an important risk factor for most not -infective chronic diseases, such as cardiovascular disease, cancer and musculoskeletal diseases. Intensive research shows that obesity reduces a healthy age and an average age by increasing the risk of these diseases, which is the most important risk factor. The study indicates that the typical effects of aging, such as muscle mass loss, atherosclerosis, insulin resistance and the decline of the adaptable immune function, are all accelerated by obesity. The researchers believe this is awakening that these health problems are increasingly observed among young people, which may indicate early signs of rapid aging. Obesity and shortening of age The two recent research groups have concluded that the physiological changes associated with obesity are similar to those seen in aging or contribute to it, which supports the hypothesis that obesity can accelerate the gradual decline in physiological safety that usually occurs in advanced living organisms. Although the relationship between obesity, the shortening of age and raising the risk of early chronic diseases is rooted, the understanding of the specific molecular pathways and mechanisms that connects them is still limited, but the study shows that both phenomena share many physiological features, such as physiological inflammation, the imbalance of the intestinal microbium, the poor nutritional sensor, the poor communication sensor, the poor communication sensor. cells. With the expectation that about a billion people will suffer from obesity by 2030, the world approaches a future in which the population worldwide can be greater than indicated by the current social and demographic data, which puts the efforts of health, functional and successful aging. To verify the hypothesis that obesity accelerates the aging, the researchers relied on a group “Santiago Live Study” in Chile, the oldest birth group in the country, which in September 1992 began to study the effects of nutrition on children’s health. At the age of 28 to 31, the average body mass index in this group was 29, and 39% of them suffered from obesity, without gender differences. The clinical trials of these young people showed disturbing marks indicating an acceleration in a healthy decline that is not in line with their time ages. It has been shown to face high cardiovascular risks, such as high blood fat levels, high blood pressure and an increase in the pulse wave velocity, which are indications often associated with the elderly or those with chronic diseases. The hypothesis of chronic obesity. The results also revealed that a disturbing increase in the rate of metabolism syndrome and fatty liver disease associated with metabolic imbalance, as the percentage at the age of 23 increased from 15% to 24%, was between 38% and 55% at the age of 29 years. More concerned that 13.7% of participants have already started using medication to control glucose, blood pressure or cholesterol levels by 28 to 31 years old. The researchers believe that these indicators are combined suggests that chronic exposure to obesity has accelerated the rate of biological aging they have, which is considered physiological at this time as natural or expected. The results revealed the fundamental differences between the three groups, especially a clear acceleration in the indicators of biological aging in the participants who suffered from prolonged obesity to judge the hypothesis of chronic obesity over the acceleration of biological aging, researchers collected blood samples from 205 participants in three groups. The first group (89 participants) constantly maintained a healthy body mass index, and the second group (43 participants) has suffered from obesity since adolescence, while the third group (73 participants) included individuals who had obesity obesity. The study focused on measuring a major subject of aging: the genetic life that depends on the patterns of the SO call DNA to estimate the biological age; The length of the telomeres, which are the protective lids at the end of chromosomes, where its brevity is an indication of cellular aging. In addition, secondary results were analyzed which include growth factors and outdated traps, proteins that play crucial roles in inflammation and cellular communication. Participants have also undergone an accurate evaluation of their metabolic heart features, with the aim of making an extensive image of chronic obesity effects on the body with age. Facts about Obesity World Health Organization In 2022 there was one person living with obesity from every 8 people in the world. Obesity figures in adults around the world have risen more than twice since 1990, and their rates have multiplied four times. In 2022, there were 2.5 billion adults (18 years or older) with weight gain, of which 890 million people live with obesity. In 2022, there were 43 % of adults at the age of 18 and too much overweight and 16 % of them lived with obesity. In 2024, there were 35 million children under the age of five with weight gain. In 2022, there were more than 390 million children between the ages of 5 and 19 years of weight gain, including 160 million children and teenagers who lived with obesity. The results revealed fundamental differences between the three groups, the most prominent of which is a clear acceleration in the indicators of biological aging among the participants who suffered from long -term obesity (groups 2 and 3), compared to those who maintained a healthy weight (Group 1). Funny disorders and the two groups of obesity showed genetic ages that exceeded their time age at a rate of between 4.4 and 4.7 years, an increase of up to 16.4%, and the difference in some cases reached about 48%, and telomeres reflected more, reflecting the accelerated cellular aging. Similarly, they have recorded high levels of signs of peripheral inflammation, reflecting the presence of chronic “agitatitis”. These indicators are associated with prominent metabolic and physiological disorders, such as raising the waist circumference, systolic hypertension, higher levels of insulin and insulin resistance, high metabolic syndrome indicators, and lipid liver risk associated with metabolic imbalance. The post -mortem of the Mitochondria tribe and a poor nutritional sensor also emerged. The researchers say that the effects of biological aging were the same among those who began obesity in early childhood and who began adolescence, suggesting that the most important factor is not the timing of obesity, but rather continues for a long time without interruption. This extensive study, which brought together epidemics, medicines and aging, provides strong evidence that obesity is long -term related to early physiological decline and signs of molecular aging in young people; Obesity is also highlighted as a model for rapid aging, which opens new horizons to investigation into interventions against ingestion. However, the study has some limitations. She focused on a specific population group in Chile, and the results may not apply directly to all ethnic groups. Monitoring studies also do not necessarily prove a causal relationship. But the presence of individuals with obesity without metabolic heart disease, and who have shown accelerated genetic ages, supports the idea that obesity can independently release signs of aging, which later leads to a metaphysical functional imbalance. These results are an important research challenge to determine the rapid development of the metaphorical heart disorder from real diseases in individuals suffering from accelerated aging due to obesity. The researchers say that, given that the phenomenon of premature aging is related to genetic genetic changes in individuals of the childhood, future research should be discussed in the possibility of inheriting this phenomenon.