Study: 200 Brain Protein can cause gossip

A recent study showed that there are more than 200 different types of distorted proteins in the brain of an elderly mice that are believed to be associated with dementia; The cognitive decline associated with age. The cognitive decline in the various memory fields is a common feature of aging, even in the absence of neurological degenerative diseases, but this decline is not inevitable; Some individuals retain cognitive abilities comparable to the abilities of young people, even in advanced stages of their lives. Scientists believe that identifying the molecular features that keep flexible individuals cognitive, or those who change in people with cognitive disability, can provide opportunities for prevention or treatment from age -related cognitive decline. Alzheimer’s disease research has long focused on two main types of protein; These are ‘amyloid beta’ and ‘tao’, which are two protein deposits that can kill nerve cells and affect the functions of the brain. But the new study, conducted by researchers at Johns Hopkins University, USA, appears upside down, indicating that these proteins are not alone on the battlefield. The author, Stephen Farid, assistant professor of chemistry and protein at Johns Hopkins University, said amyloids are lumps of large, clear and easy to see proteins under a microscope, so it is of course getting the attention of scientists. He added: “But we now see hundreds of protein being distorted without gathering in the form of amyloids, but it seems to clearly affect the performance of the brain.” The study included an analysis of 17 -year -old brains, all of which originated in the same circumstances. 7 of which a poor performance in memory tests and problem solving showed, and that she was of the opinion that she had suffered cognitive twice, while ten similar performances at the age of 6 months showed small mice. The research team focused on the strongholds, which form part of the brain responsible for memory and spatial leather, and valued more than 2500 types of protein; For the first time, scientists were able to distinguish between the proteins that retained their natural form and those who were deformed or bad. The study achieved remarkable results, as more than 200 species of distorted protein in the brain of mice with cognitive weakness were identified, while proteins remained intact in mice with natural mental abilities, increasing the hypothesis of their association with the decline of memory -related memory. The study says that not -re -fold -protein, that is, those who lose their ability to return to their normal form after being damaged are closely related to cognitive decline. Not -folding protein are protein molecules that do not take the right three -dimensional structure that enables them to perform their biological functions naturally, and often accumulate within cells or tissues, which cause severe cellular disorders as these proteins are associated with a number of degenerative and neurological diseases such as Alzheimer, Parkinson, and Huntington. Structural changes and the loss of protein lead to a proper folding ability to form insoluble events known as protein blocks that impede important cellular processes and cause a defect in the protein balance in the cell. The danger is that these proteins, once they lose their fold, cannot recover it, not even after isolated from their original cellular environment, which distinguishes them from proteins that can restore their original structure if the appropriate conditions are available. Failure to post “return to origin” places scientists before a tremendous challenge in the fields of molecular and pharmaceutical biology, especially as these proteins can be the product of accurate genetic mutations, or stressful environmental conditions, or simply because of aging, which makes them an important indication of the aging of the cell and the functional stability of the cell. What is protein? Protein is a large molecule consisting of a series of amino acids. It is one of the most important basic building blocks in the cells of the body. It is included in the construction of muscles, enzymes, hormones and antibodies. Each protein has a special arrangement of amino acids that determine its function, and the study found that these proteins are 2.7 times more likely to show structural changes associated with perception; Among the protein with structural changes associated with the perception, 14 out of 15 proteins of a non -re -fold. The researchers said that not -coalition formative changes in the structure of proteins can be a common characteristic and cause of cognitive decline, and this interpretation supports the absence of adequate evidence indicating that the translation of the translation; Like phosphory and oxidation, it is responsible for the majority of these structural changes. The results indicate that the imbalance in the fold of proteins can be harmful, even without the formation of amyloid blocks that have long been held by Alzheimer’s, which opens a new door to a broader and more complicated understanding of the disease. What is the “fold” process? The process in which the amino acid tape becomes in a specific 3D form. The final form of protein is what determines its function in the cell. Fetal is automatically in the cell, using some auxiliary protein. If the protein does not fold properly, it can lose its function or cause diseases such as Alzheimer’s or Parkinson. Stephen Farid added: “We always thought that the danger lies only in the protein that collects and shapes blocks, but we now discover that there are many types of proteins that can be distorted without coming together, yet cause real problems.” In normal circumstances, cells have a monitoring mechanism known as a ‘protein quality system’ that detects and destroys distorted protein, but the study shows that some of these proteins are able to escape from this defense system, which arise important questions about how it occurs. The research team is now planning to use a microscope with a high precision to carefully see this distorted protein, hoping to understand the micro structural distortions it goes through. This study is an important step towards the development of a treatment that targets wider types of deformed protein, and not just ‘amyloid beta’, or ‘Tao’, which can lead to more effective interventions to reduce mental decline in the elderly. The researchers acknowledged that the study is monitoring and does not directly prove the causal connection, nor does it determine the accurate mechanism of these variable protein formations or its continuation. However, the strong association between protein with structural changes associated with perception and non -folding protein provides indirect evidence that these features arise from a general basic cause, namely that the protein is complicated to fold or subject to bad fold.