A study that connects rare genetic variables using the left hand

In a recent study, new evidence was revealed, suggesting that rare genetic variables play an important role in using the left hand. The study, published in the journal Nature: Jinxx on Tuesday, highlights the complicated genetic basis for using one of the hands, and the potential connections with nervous growth deviations. Depending on the genetic data collected from about 350,000 people, the study showed that rare coding variables play an important role in determining the use of the left hand. These results dispute the old assumptions about environmental factors that affect the use of one of the hands, and provide new visions on the development of the incompatibility of the brain. “Rare coding variables” and the use of one of the hands, which is a reflection of the specialization in the hemisphere, the interest of scientists for a long time; Because of its distribution among people and its association with very nervous conditions. While the studies are linked to the previous genome level, the general genetic effects have identified the use of one of the hands, but this new study deepens more in the role of rare coding variables, which are less than 1%. By analyzing the genome data of approximately 38,000 people from left and 313 thousand, the researchers determined an incredible relationship between rare coding variables in a gene known as TubB4B, and the use of the left. These variables are 2.7 times more in people using the left, compared to their peers using the right hand. Previous studies have shown that genetics, together with environmental, cultural and social factors; It plays a role in the election to use one of the hands, and research indicates that the use of the left hand tends to spread in families, indicating the presence of a genetic element in the use of the left hand, but the specified genes and their exact role in determining the use of one of the hands are still under study. Hand control is closely related to the lack of consistency of the brain, especially in the areas responsible for motor control and language processing; The differences in the development of these brain areas can affect the use of one of the hands, for example, some studies have found that differences in the structure and function of the cerebral hemisphere between people using the left hand and people using the right hand. The lead author of the study, Clyde Franks, who leads the genome Plastic Research Group at the Max Planck Institute in the Netherlands, says that scientists know that hemors of the cerebral football are already in the human fetus in evolution, but the mechanism is unknown. He explained to “Al -Sharq” that finding genes associated with the contradiction of the brain or behavior, such as using one of the hands, can provide some evidence. What is TubB4B gene? This gene encodes a cell protein of a family known as the ‘Topolin Family’, which is the basic building blocks of microcredite, which is a thread in the cells that play crucial roles in different cellular processes. And with people using the left hand; This gene contains changes in the DNA order, that is, the arrangement of the letters that make up the DNA, and thus leads to differences in the opposite protein produced by the gene. The presence of rare coding variables means that certain genetic mutations or changes within this gene can be associated with the increase in the possibility of the left hand, and these rare variables are not regularly found in the general population, and unique genetic characteristics can occur in individuals who tend to use the left hand. Franx tells Al Sharq that the variables in the TubB4B -no the protein structure integrated into the finishes will change; Which in turn changes the way it controls in the forms and movements of cells. “This means that the fine pipes are involved in creating normal asymmetry in the brain, such as language dominance in the left half of the world and control of the hand.” When does the change happen? ‘Franken’ says that the change in the fetal brain occurs, as the exact tubes can help create the left and right part of the brain, by giving some cells as an asymmetric development at a certain stage. The microscopic pipes in the cilia, which are bumps from the surface of the cell supported by the exact pipes, can lead to asymmetric movements and fluid flow to the brain while forming. 90% of people prefer to use the right hand, which is already visible in embryonic movements that have not yet been born because it is clear from the ultrasound scan, and ‘Franken’ says that the use of the right hand is the standard result of early brain growth as it is coded by the genome, and that people who use the left hand. Apart from the native country, the preference of the use of one of the hands is related to cultural heritage, “the use of the left is only weak for environmental factors or early life factors studied so far, such as twins, breastfeeding and medical problems associated with childbirth” according to the lead author of the study. Franx believes that most cases of left hand are simply occurring due to the random difference during the growth of the fetal brain, without specific genetic or environmental effects, and, for example, ‘random fluctuations in certain molecule concentrations during the capital of brain formation for example.’ The research objectives “Franks” began working almost 25 years ago on the contradiction of the brain and its relationship. He says that this work has greater effects in the field of psychiatry, and this can affect the understanding of the mechanisms of the brain difference and how it affects the willingness of brain diseases. He explained that “one of the important objectives of this field is the division of general diagnoses, such as autism, which depends on the characteristics of behavior, in a number of different diagnoses that are more focused on biological causes; therefore, determining a subgroup affected is the change of the development of the inconsistence of the brain, a function that contributes to the achievement of this goal.” Franx confirms that there are also some possible psychiatry connection, as “using the left hand is more common in cases of autism and schizophrenia compared to the general population, so that the lack of consistency of the variable brain caused by genetic variables can distinguish a sub -group of people affected, because it is clear that most people who use the left hand not. ” Therefore; The results will not only increase the understanding of the genetic basis for the use of one of the hands, but also open new ways to investigate the complicated interaction between genetics and in harmony with the brain and nerve growth disorders.