Researchers develop a new substance that can treat damaged cartilage

Scientists from the American University of North Western have developed an active important material that has succeeded in renewing high -quality cartilage in the knee joints of a large animal model, in a move that is a great achievement in renewal medicine. Although this innovative substance seems to be rubber and sticky, it is a sophisticated network of molecular components designed to simulate the natural environment of cartilage in the body. Cartilage damage, often caused by injuries or degenerative diseases such as osteoporosis, is an important medical challenge, and unlike other tissues, cartilage has a limited ability to recover, due to the non -vessel card and low cells. The treatment of degenerative diseases and providing traditional treatments, including surgical interventions and physical therapy, limited comfort, and does not address the cause of the problem. The active biological material developed by scientists at the University of North -West Western is a new approach that is different from traditional methods. This substance consists of a complex network of molecular components, and is designed to simulate the natural environment of cartilage, and its unique structure is easy to combine with the tissue of the body, which improves natural recovery processes. In the new study, published in the American Academy of Science Academy, the researchers worked to apply the material to damaged cartilage in the animal cracking joints. In just 6 months, the researchers noted evidence of reinforced recovery, including new cartilage growth containing natural biological polymers, collagen and proteincan, which allows pain -free mechanical flexibility in the joint. The researchers reported that the new material could one day be used to prevent complete knee replacement operations, and to treat degenerative diseases, such as osteoporosis, and the recovery of mathematical injuries, such as anterior cruciate ligament tears. And cartilage is an essential element in the human joints, and if it is destroyed or collapsed over time, it can have a significant impact on people’s overall health and movement. The problem is that cartilage in adults does not have the ability to heal, and that new treatment can stimulate recovery in tissues that are not naturally renewed. The team used “dancers” to activate human crackle cells, to improve the production of protein that builds a tissue matrix, in addition to a hybrid biological substance, consisting of vital peptide, linked to the transformer growth factor, known as Beta-1 (TGFB-1), which is a basic protein and maintenance. Hyalurine acid, found in crack-moisturized fluid, and it is a crack-moistened moisture, and has in the crack-moisturized moisture. joints. The active biomassic team merged and the chemically modified hyaluronic acid molecules to push the self -regulation of nano particles into a package that mimics the natural structure of cartilage. The goal was to create an attractive scaffold for body cells to regenerate cartilage tissue, and using active important signals in nano particles, encouraging the material cartilage repair through cells filling the scaffold. Knee joint cartilage and to determine the effectiveness of the material in the promotion of cartilage growth, the researchers have used the testing in sheep suffering from cracking fects in the knee joint, which is a complex joint in the rear ends that look like the human knee. The test in the sheep model was essential, as sheep cracking bone corresponds very much with those in humans, in terms of weight, size and mechanical loads, in addition to the problems of renewing it. The study on the sheep model allows researchers to predict how to work with people. In other smaller animals, a cartilage -regeneration occurs more easily. The researchers injected the thick fabric that looks like putty in cracking fates, as it turned into a rubber matrix, not only the new cartilage to fill the defect, but the tissues that were stuck are constantly higher quality compared to the control group. The treatment of cartilage damage and in the future researchers suggest that the new material can be applied to the joints during open or endoscopic joint operations. The current standard of care is accurate fracture operations, where surgeons create small fractures in the primary bone to stimulate the growth of new cartilage. But the biggest problem in the accurate breaking approach is that it often leads to the formation of fibrous cartilage, the same cartilage in the ear, unlike the cartilage of the glass, which is the cartilage we need to get functional joints. By renewing the cartilage of the glass, this approach should be more resistant to corrosion and damage, and to solve the problem of poor movement and joint pain in the long run, while avoiding rebuilding the joint with large pieces of devices. The researchers pointed out that this biologically active substance, which succeeds in the large animal model, has major consequences for human health. And if it is possible to repeat similar results in human experiences, this innovation can make the treatment of cartilage damage a revolution, providing a new path for patients suffering from joint pain and movement problems. The possibility of high quality cartilage regeneration can reduce the need for joint replacement operations, and improve the quality of life for millions of individuals around the world.