Creating a new system to deliver medication in the body with sugar

US researchers have invented a new system to deliver medication in the body based on ultrasound particles. The results of the study, published by the magazine “Nature: Nanotechnology”, said that the system could release the drug at a specific location within the body with an accuracy of only a few millimeters. This innovation can succeed in reducing the serious side effects associated with many medications, from depression and pain relievers to cancer medication, by ensuring that the drug reaches its purpose directly without affecting healthy tissues. The side effects of the medicine have long been a pain reliever causing nausea to depression medication, by chemotherapy that harms healthy cells, a chronic problem in the world of medicine. The new idea depends on the pharmaceutical packaging in nano particles called Lypezomat and is similar to those used to pack the DNA particles in the anti -Corona virus vaccines. These molecules, of course, wander the bloodstream, but they only release the drug when exposed to ultrasound concentrated from outside the body. The drug can therefore be released into a specific accuracy area of only a few millimeters, either in the brain, nerves or targeted tissues. The key that the system made in practice this time was not a complicated or rare substance, but rather a little sugar, as researchers at Stanford University discovered that the addition of a Scripture solution to a concentration of 5% in the molecules stable in the body and subject to ultrasound. The research team led by Raj Ern, assistant professor of radiology, through the experiments of mice, succeeded in connecting the ketamine medicine with specific areas of the brain, which inhabited the nerves in the limbs. When the researchers injected mice with free, non -covered, the remedy, the remedy was found in most parts of the body, such as the brain, liver, kidneys, spleen, heart and lungs. But with the ketamine covered with nano particles, the focus of the drug decreased by more than half in all these organs. If directed by ultrasound to a specific area of the brain, the concentration of the vitamin has increased to 3 times compared to the rest of the regions. The accuracy of target allowed to reduce the behavior of anxiety in mice when the ketamine was released in the front frontal area for the control of emotional cases; It opens the door for the use of ketamine in the treatment of depression and mental disorders without causing its unwanted separatist effects. The researchers tried to use a local housing – a ropakayin – to numb the sciatic nerve. After a short ultrasound session that extends about 2.5 minutes, one leg of the mouse for about an hour did not become sensitive to pain, without needing direct injection in place of pain; This feature means that patients can get localized housing without a painful tingling or surgical intervention. The team’s efforts to connect ultrasound medication go back to 2018, when it used more complicated combinations to deliver chemicals to the brain, but the previous copies were inaccurate; It needs rare chemical compounds, storage in high temperatures and a limited amount of drug in the molecules. The team benefited from the experience of the enormous infrastructure that arose after the Corona vaccines to produce Lipozomat; Although additives such as salts and polymers could not cause the necessary balance, sugar molecules have density and viscosity suitable for the interaction of molecules with ultrasound. The research team is preparing for a first clinical experience on people, which aims to use ketamine to relieve the emotional experiences of chronic pain, and seriously say that this version ‘clinically valid’ is much more than previous attempts. “This time a little sugar made it possible. It applies easily, and it can open the way for a new era of accurate guided medicine.” If the technique proves its success in human experiences, it can radically change the way medication is given: safer and more effective medication, with lower side effects, by taking advantage of nano particles and not -surgical ultrasound, and it can be the future treatment that replaces painful injections and toxic treatments, already in stanford lab.