A new experimental remedy that can help treat 'dwarf' in children
A recent study has shown that one tablet daily from the experimental remedy ‘Inigratinib’ helps to effectively increase the length and improve limbs growth in a proportional way in children with ‘acondroplasia’, which is the most common form of ‘dwarf’. The results show that these promising medicines can release these children from the need for daily injection to increase growth. There are more than 300 different cases that can lead to a short stature, and among these cases, the Akonroblazia is the most common stature species, as it affects about 1 at 15 thousand to 1 out of 40 thousand people. This condition causes the arms and legs to shorten the head and torso, and people with ackerboblazia can also have a larger head and poor muscles, in addition to this disease, it can cause other genetic conditions, kidney disease, metabolism or hormones, as well as stature. This disturbance causes shortening of the ends while maintaining the length of the natural stem due to a mutation in the FGFR3 gene, a gene responsible for the growth of the bone, which disrupts the process of turning cartilage into a long leg, such as legs and arms. An effective treatment, and the study published in the New England Journal of Medicine, has shown that the experimental means of the infigratinib are safe and effective in treating children between the ages of 3 to 11 years and with this type of stunt. Infigratinib is used to treat a type of cancer that affects bile ducts, a type of medicine that works by FGFR2 fiber growth receptors to target and impede and impede an important role in regulating cell growth and development. And when infigratinib is inhibited for excessive FGFR2 receptors in cancer cells, it reduces the growth and distribution of cancer cells. Infigratinib is taken orally in the form of tablets, usually once a day, and in most cases it is taken for 21 consecutive days, followed by 7 days without treatment in a 28 -day treatment cycle. The lead author of the study, Ravi Savariran, said that infigratinib not only increases bone growth but also improves the quality of the lives of infected children. The study included 72 children from Australia, Britain, the United States, Spain, France and Canada. The study showed that the drug was effective in increasing the growth rate by 2.5 centimeters annually during the treatment, with a noticeable increase in the total length and the percentage between the upper and lower part of the body. Although there are some minor side effects, no serious negative reactions have been recorded among the participants. The daily treatments have added that the study showed that infigratinib is a safe and effective agent to increase growth in children with aconroblazia, and it can fill the need for oral medicine for this condition “and it is considered very important for children who do not tolerate daily injection, and also in areas where oral medicines are convenient as injection.” Infigratinib is a new hope for children with aconroblazia and their families as it can contribute to improving their lives significantly without being treated daily. The team started in the third phase of experiments, and there is planning for additional studies that include children between the age of a day and 3 years and those with Eckedroplasia.