Japanese researchers develop a new mechanism to target cancer cells

Researchers at the Japanese University of Nagoya have developed a new mechanism for the treatment of cancer and genetic diseases, by providing the possibility of operating protein production in targeted cells, without affecting healthy cells, which paves the way for accurate treatment of these diseases. This mechanism is a prominent achievement in the field of the treatment of MRNA, known as the “translation mechanism stimulated by the interior cover”. According to the study published in the journal “Nature Biotechnology”, this technology depends on the new generation of treatments based on the Ribzi -pinned DNA, which is more stable and less stimulating infections, compared to its traditional linear counterpart, and is characterized by its high resistance to dissolved traditional points. “Transplant process” for a longer period. However, the biggest challenge facing previous research was the weakness of the effectiveness of translation into living organisms, as previous efforts were based on internal ribosome imports that were difficult to adapt and low efficiency. The Japanese team improved protein production and to circumvent this obstacle, creating the structure of a circular ribzi acid covering, which could effectively start the translation, which led to a significant improvement in the production of protein. Imagine having an encrypted message that only the target person can read, and this is the most important idea behind the new mechanism developed by the researchers. Usually, the marinated ribosic DNA is written, which quickly makes it vulnerable to decomposition, and needs special signals in the cell to start producing protein, but scientists have found a way to turn it into a circular shape that makes it more stable and longer. Eliminate cancer cells, but the problem with this circular DNA was that it was not easily translated into a protein in the body; Due to the problems of identifying cell mechanisms. Here comes the solution; Instead of relying on traditional signals that are often ineffective, the researchers added a special part similar to an “internal cover” to this DNA, which enabled it to produce protein more efficiently. This discovery opens the door for revolutionary therapeutic capabilities, as this DNA can be programmed to produce useful proteins in the cells you need, such as the production of healthy proteins in cases of genetic diseases, or designing to produce toxic substances within cancer cells to affect it only without having healthy cells, which make this technology a great step. In the current treatments, which depend on cell education to produce certain proteins, there are two most important problems: the first is that genetic instructions are often ineffective, and the second is that these instructions quickly dissolve, which the patient must regularly give doses. But thanks to the new method, scientists were able to develop an improved type of genetic material called “Cap-Sirch Rana”, which can produce protein in larger amounts of up to 200 times compared to previous methods, while staying stable for long periods of time without breaking up quickly. This means that the treatments that depend on this technique will become more effective and the least needed for regular doses. Immune treatments. Scientists believe that this technique will change the future of medicine as it can be used in immune treatments, correcting genetic errors and compensation for lost protein, which can help treat disease such as muscle infection, which is a disorder caused by the body’s inability to produce important protein for muscle health. The researchers say that this mechanism is also a revolutionary approach in the treatment of cancer, as it can target cancer cells without harming healthy cells, reducing the side effects of traditional treatments; It depends on the target of the long -term ribzi acid that is expressed too much in some cancers. To test the effectiveness of this technique, the researchers have designed a circular molecule of genetic material that can target a specific type of nucleic acid that occurs in liver cancer cells. A qualitative shift and when this molecule entered the cancer cells, it increased the production of protein by 50 times compared to the normal condition, but without affecting healthy cells, and that means that the new technology can accurately distinguish between sick cells and normal cells, which is an important step towards more accurate and less harmful treatments for the body. Scientists believe that this method can be used to produce toxic protein in cancer cells, which results in killing them in a program without affecting healthy tissues by stimulating a specific immune response. The study also indicates that there are similar natural mechanisms that can occur in the body, which can help with a deeper understanding of how proteins are produced within cells, and the use of this concept in developing new treatments for a wide variety of diseases. This discovery represents a qualitative shift in genetic treatment research, and also increases the ability to develop more specialized techniques for treating diseases with unprecedented precision.