أرشيف الوسم: Epidemiology

Potential prostate most cancers biomarkers | VUMC Reporter

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by Leigh MacMillan

Biomarkers for screening and early detection of prostate most cancers — the most typical and second deadliest most cancers in U.S. males — are restricted. PSA (prostate-specific antigen) is extensively used however is controversial due to its unclear profit and contribution to prostate most cancers overdiagnosis.

Wei Zheng, MD, PhD, and colleagues used genetic instruments to seek for associations between genetically predicted blood protein ranges and prostate most cancers threat. They studied 79,194 circumstances and 61,112 controls of European ancestry from a number of prostate most cancers consortia.

They recognized a complete of 31 proteins related to prostate most cancers threat. 9 of the proteins are encoded by genes situated at GWAS-identified prostate most cancers threat loci, and a number of other have potential useful roles in prostate most cancers growth. For 28 of the proteins, gene modifications had been detected in tumor tissues from sufferers with prostate most cancers included in The Most cancers Genome Atlas program.

The big-scale research, reported in Most cancers Analysis, generates a listing of promising proteins as potential biomarkers for threat evaluation and early detection of prostate most cancers.

This analysis was supported partially by funds from the Anne Potter Wilson endowment and grants from the Nationwide Institutes of Well being (CA218892, CA160056).

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Shu, Zheng obtain Vietnam’s prime honor for overseas scientists | VUMC Reporter

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by Tom Wilemon

The Vietnamese Ministry of Well being has awarded two Vanderbilt epidemiologists the Memorabilia Medal “For the Folks’s Well being” in appreciation for his or her contributions in serving to the nation set up a population-based analysis program for most cancers, diabetes and different non-communicable illnesses.

The medal is the very best honor that the Vietnam authorities bestows upon overseas scientists who’ve made important contributions in public well being. Previous recipients have included representatives of the World Well being Group and different worldwide well being specialists.

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Xiao Ou Shu, MD, PhD, MPH

Xiao Ou Shu, MD, PhD, MPH, affiliate director for World Well being and co-leader of the Most cancers Epidemiology Analysis Program at Vanderbilt-Ingram Most cancers Middle, and Wei Zheng, MD, PhD, director of the Vanderbilt Epidemiology Middle and Anne Potter Wilson Chair in Drugs, acquired the medals in July. Shu led a workforce of Vanderbilt researchers on a program to construct analysis capability in Vietnam that’s supported primarily by a grant from the Nationwide Most cancers Institute’s (NCI) Middle for World Well being. This grant is a part of NCI initiative to create and assist Regional Facilities of Analysis Excellence for non-communicable illnesses in low- and middle-income international locations or areas. Shu is the lead principal investigator of this grant.

“We all know that illness has no borders,” Shu stated. “This analysis advantages America additionally as a result of what we study in a foreign country may be transferred again to the U.S. populations, notably for some life-style habits, comparable to weight loss program and train, and genetic elements which are tough to review on this nation because of their low prevalence.”

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Wei Zheng, MD, PhD, MPH

She cited for example a earlier research she led on soy consumption amongst breast most cancers survivors that exposed soy merchandise within the weight loss program had been related to a diminished breast most cancers recurrence fee regardless that they comprise giant quantities of isoflavones that bind to estrogen receptors in cells. Estrogen is a hormone that has been linked to most cancers development, notably in breast most cancers. The research confirmed that ladies who ate probably the most soy meals, greater than 11.83 mg isoflavones per day, had a 27% diminished fee for breast most cancers recurrence in comparison with those that had the bottom consumption. Such a research would have been tough to conduct with out utilizing a Chinese language-based population-based research as a result of soy will not be generally consumed within the U.S. and consumption is low and tough to measure, Shu stated. This discovering has led to a change of dietary tips from the American Most cancers Society for breast most cancers survivors.

The Vanderbilt epidemiology workforce labored with the NCI, the Vietnamese Nationwide Most cancers Hospital and Institute, the Hanoi College of Public Well being and Hanoi Medical College to ship coaching and capability constructing workshops and in-person coaching classes and to share their experience on survey questionnaires, analysis protocols for gathering biospecimens, biobanking and high quality management. They traveled with Vietnamese scientists to go to analysis laboratories in the USA and in Asian international locations. They mentored them on statistical evaluation and writing scientific papers.

“Non-communicable illnesses have now turn into an issue for Vietnam because the society has transitioned from a low-income inhabitants to some extent a middle-income inhabitants now,” Zheng stated. “Persistent illnesses have turn into extra widespread.”

Along with the NCI-sponsored work, Shu and her workforce additionally contracted with the VINMEC Worldwide Hospital in Vietnam to develop analysis applications in colorectal most cancers epidemiologic analysis.

The work in Vietnam started in 2015 when Shu and Zheng traveled there for a wants evaluation. In 2017, Shu obtained a two-year NCI grant together with Thuan Van Tran, MD, director of the Vietnam Nationwide Most cancers Hospital because the joint principal investigators.

The Vanderbilt workforce additionally helped Vietnamese investigators publish a particular version of Most cancers Management dedicated to cancers in Vietnam that included 17 peer reviewed papers. Shu, together with two Vietnamese researchers, was one in every of three visitor editors of the particular version, which coincided with the 50th anniversary of the Nationwide Most cancers Hospital.

A number of Vanderbilt professors co-authored a few of these research, together with Martha Shrubsole, PhD, analysis professor of Drugs, Division of Epidemiology, Stephen Deppen, PhD, an epidemiologist and assistant professor of Thoracic Surgical procedure, Staci Sudenga, PhD, assistant professor of Epidemiology, and Jaleesa Moore, PhD, an Epidemiology postdoctoral fellow. Sang Minh Nguyen, a Vanderbilt graduate scholar from Vietnam pursuing his PhD beneath the mentorship of Shu, additionally contributed to the publication.

Zheng stated he welcomed the chance to assist make a distinction in Vietnam. “They want this type of assist and we’ve the capability to assist them,” he stated.

Shu stated Vietnam has a possibility to forestall some power illnesses associated to weight loss program and life-style.

“You place out the fireplace earlier than it will get aflame,” she stated. “That’s necessary.”

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Shu, Zheng obtain Vietnam’s high honor for overseas scientists | VUMC Reporter

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by Tom Wilemon

The Vietnamese Ministry of Well being has awarded two Vanderbilt epidemiologists the Memorabilia Medal “For the Individuals’s Well being” in appreciation for his or her contributions in serving to the nation set up a population-based analysis program for most cancers, diabetes and different non-communicable illnesses.

The medal is the best honor that the Vietnam authorities bestows upon overseas scientists who’ve made important contributions in public well being. Previous recipients have included representatives of the World Well being Group and different worldwide well being consultants.

blank
Xiao Ou Shu, MD, PhD, MPH

Xiao Ou Shu, MD, PhD, MPH, affiliate director for International Well being and co-leader of the Most cancers Epidemiology Analysis Program at Vanderbilt-Ingram Most cancers Middle, and Wei Zheng, MD, PhD, director of the Vanderbilt Epidemiology Middle and Anne Potter Wilson Chair in Drugs, acquired the medals in July. Shu led a workforce of Vanderbilt researchers on a program to construct analysis capability in Vietnam that’s supported primarily by a grant from the Nationwide Most cancers Institute’s (NCI) Middle for International Well being. This grant is a part of NCI initiative to create and assist Regional Facilities of Analysis Excellence for non-communicable illnesses in low- and middle-income nations or areas. Shu is the lead principal investigator of this grant.

“We all know that illness has no borders,” Shu mentioned. “This analysis advantages America additionally as a result of what we study in a foreign country might be transferred again to the U.S. populations, significantly for some way of life habits, resembling weight loss plan and train, and genetic components which can be tough to check on this nation on account of their low prevalence.”

blank
Wei Zheng, MD, PhD, MPH

She cited for instance a earlier research she led on soy consumption amongst breast most cancers survivors that exposed soy merchandise within the weight loss plan have been related to a decreased breast most cancers recurrence fee though they comprise giant quantities of isoflavones that bind to estrogen receptors in cells. Estrogen is a hormone that has been linked to most cancers progress, significantly in breast most cancers. The research confirmed that ladies who ate essentially the most soy meals, greater than 11.83 mg isoflavones per day, had a 27% decreased fee for breast most cancers recurrence in comparison with those that had the bottom consumption. Such a research would have been tough to conduct with out utilizing a Chinese language-based population-based research as a result of soy will not be generally consumed within the U.S. and consumption is low and tough to measure, Shu mentioned. This discovering has led to a change of dietary tips from the American Most cancers Society for breast most cancers survivors.

The Vanderbilt epidemiology workforce labored with the NCI, the Vietnamese Nationwide Most cancers Hospital and Institute, the Hanoi College of Public Well being and Hanoi Medical College to ship coaching and capability constructing workshops and in-person coaching periods and to share their experience on survey questionnaires, analysis protocols for amassing biospecimens, biobanking and high quality management. They traveled with Vietnamese scientists to go to analysis laboratories in america and in Asian nations. They mentored them on statistical evaluation and writing scientific papers.

“Non-communicable illnesses have now grow to be an issue for Vietnam because the society has transitioned from a low-income inhabitants to some extent a middle-income inhabitants now,” Zheng mentioned. “Persistent illnesses have grow to be extra widespread.”

Along with the NCI-sponsored work, Shu and her workforce additionally contracted with the VINMEC Worldwide Hospital in Vietnam to develop analysis packages in colorectal most cancers epidemiologic analysis.

The work in Vietnam started in 2015 when Shu and Zheng traveled there for a wants evaluation. In 2017, Shu obtained a two-year NCI grant together with Thuan Van Tran, MD, director of the Vietnam Nationwide Most cancers Hospital because the joint principal investigators.

The Vanderbilt workforce additionally helped Vietnamese investigators publish a particular version of Most cancers Management dedicated to cancers in Vietnam that included 17 peer reviewed papers. Shu, together with two Vietnamese researchers, was certainly one of three visitor editors of the particular version, which coincided with the 50th anniversary of the Nationwide Most cancers Hospital.

A number of Vanderbilt professors co-authored a few of these research, together with Martha Shrubsole, PhD, analysis professor of Drugs, Division of Epidemiology, Stephen Deppen, PhD, an epidemiologist and assistant professor of Thoracic Surgical procedure, Staci Sudenga, PhD, assistant professor of Epidemiology, and Jaleesa Moore, PhD, an Epidemiology postdoctoral fellow. Sang Minh Nguyen, a Vanderbilt graduate scholar from Vietnam pursuing his PhD beneath the mentorship of Shu, additionally contributed to the publication.

Zheng mentioned he welcomed the chance to assist make a distinction in Vietnam. “They want this type of assist and we have now the capability to assist them,” he mentioned.

Shu mentioned Vietnam has a possibility to forestall some continual illnesses associated to weight loss plan and way of life.

“You place out the fireplace earlier than it will get aflame,” she mentioned. “That’s necessary.”

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Biomarkers of DNA methylation can be a predictor of breast cancer risk | VUMC Reporter

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by Tom Wilemon

Biomarkers of DNA methylation, which regulate gene expression, can be a predictor of breast cancer risk, according to a study published in Journal of the National Cancer Institute.

Vanderbilt’s Jirong Long, PhD, associate professor of Medicine, Division of Epidemiology, and colleagues conducted a methylation-wide association (MeWAS) study of data from 228,951 women of European descent with the goal of identifying new genes and methylation markers associated with breast cancer risk. They discovered 450 DNA methylation sites associated with breast cancer, including 45 sites located in novel chromosome regions that had not been previously reported for breast cancer.

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Jirong Long, PhD

Integrative analyses of genetic DNA methylation and gene expression data found that 38CpGs may affect breast cancer risk through regulating expression of 21 genes.

“This study used a novel approach to investigate DNA methylation in hundreds of thousands of participants,” Long said.

In conducting the MeWAS study, Long and colleagues came up with a new methodology for identifying novel DNA methylation biomarkers that can be applied to other diseases. They first built statistical models to predict DNA methylation levels via multiple genetic variants in a reference dataset, then validated the models in independent samples, and then applied the prediction models to a large genetic dataset to test the genetically-determined methylation level with disease risk.

“Our novel methodology overcomes limitations of traditional epidemiological studies and is more accurate and powerful than studies based on a single meQTL approach,” the researchers wrote.

The research was supported by grants RO1CA158473 and R01CA148677 from the U.S. National Institutes of Health, the Anne Potter Wilson endowment and development funds from the Department of Medicine at Vanderbilt University Medical Center.

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