Dengue Virus Invades a Cell

This visualization adapted from the University of Massachusetts Medical School shows the process by which a dengue virus releases its genetic contents inside a host cell, allowing viral replication.

The key players are proteins found on the viral surface called envelope proteins, which change their structure when the virus is endocytosed, or taken inside the cell. This structural change enables the viral membrane to fuse with the endosomal membrane, and the virus’ RNA to enter the cytoplasm of a host cell. There, ribosomes will make viral proteins that will spread to other cells through the replication and secretion of new viral particles.

This video was downloaded from PBS LearningMedia. Read more about research on the dengue virus here:

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Media Credits:
©2008 WGBH Ed. Fndn. All Rights Reserved. Animation adapted from Viral Fusion ©2008 Univ. of Massachusetts & XVIVO Scientific Animation. Production:Irene Bosch, Michael Astrachan & David Bolisnky. Animation: Janet Iwasa, Gaël McGill, Digizyme Inc. Composting, editing, & art direction: Michael Astrachan, XVIVO. Narrative & data: Yorgo Modis, Yale Univ. Music production: Alonsound. Acknowledgements: Univ. of Massachusetts Medical School, Emory Univ. School of Medicine, Stanford Univ. School of Medicine, Dana-Farber Cancer Inst., Mount Sinai School of Medicine, Oklahoma Medical Research Fndn., Immunology and Cancer Program, Baylor Inst. for Immunology Research, Cooperative Centers for Translational Research on Human Immunology and Biodefense U19-AI057319, National Inst. of Allergy and Infectious Diseases, NIH. Additional images courtesy; US Dept. of Agriculture & Center for Disease Control and Prevention; James Gathany (photog.), Frank Hadley Collins & Paul I. Howell (content providers).

UMASS Medical School Center for Translational Research in Immunology and Biodefense

Project funded by:
NIH/National Institute of Allergy and Infectious Diseases

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