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Brain aging occurs at accelerated rate in patients with psychosis | Vanderbilt News

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According to a new study by Vanderbilt researchers, normal brain aging patterns in patients with a psychotic disorder occur at an accelerated rate, impacting the patient’s cognitive functioning and suggesting treatment intervention in the early psychosis period may improve long-term outcomes.

The study, published in Biological Psychiatry, used brain imaging techniques to compare the degree of interconnectivity between brain regions in patients with psychosis and healthy control subjects. Researchers specifically looked at connectivity in the frontoparietal network and cingulo-opercular network, both of which support general cognition and exhibit the earliest signs of age-related decline in healthy individuals.

The results indicated that these networks were intact in patients with early-stage psychosis, but showed a more rapid decline in patients with chronic psychosis when compared with healthy individuals of the same age range.

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