Small cell lung cancer (SCLC) represents up to 25 percent of lung cancer cell deaths and is associated with early metastasis and poor patient survival. Thus, SCLC is in need of better therapeutics and more efficient targeted treatments.
Jonathan Lehman, MD, PhD, Pierre Massion, MD,and colleagues have demonstrated that somatostatin receptor 2 (SSTR2), considered to be a cell growth inhibitor, is highly expressed in SCLC cancer cell lines as well as in primary tumors. However, the authors found that high expression of this molecule has a direct correlation to poor survival rate in SCLC patients. They found that reducing SSTR2 expression results in increased apoptosis and decreased tumor growth.